A Concise Synthesis of Forskolin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00485514" target="_blank" >RIV/68081707:_____/17:00485514 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/17:00067109 RIV/00216224:14310/17:00097892
Result on the web
<a href="http://dx.doi.org/10.1002/anie.201706809" target="_blank" >http://dx.doi.org/10.1002/anie.201706809</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201706809" target="_blank" >10.1002/anie.201706809</a>

Result language
angličtina
Original language name
A Concise Synthesis of Forskolin
Original language description
A 24-step synthesis of (+/-)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acid-modified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)