Novel Reactive Groups for Modification DNA by Oxoosmium Complexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F17%3A00506657" target="_blank" >RIV/68081707:_____/17:00506657 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel Reactive Groups for Modification DNA by Oxoosmium Complexes

Original language description

DNA is naturally electroactive moleclue producing several intrinsie voltammetric signals. Some of them found appliction in electrochemical analysis of DNA interactions and damage. In particular types of applictaions is a suitable use DNA labelling by redox active tags to increase selectivity and sensitivity of analysis.One type of long-term used tags are complexes of osmium tetroxide with nittrogen ligunds (Os,L). These complexes preferentially react with pyrimidines in single stand DNA producing electractive adducts. primary reaction site for Os,L is C-C double bond in pyrimidine nucleobases. In this contribution will be presented results acquired with DNA containing chemically modified nuclebase.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project

<a href="/en/project/GA15-08434S" target="_blank" >GA15-08434S: Novel reactive groups introduced in nucleic acids for modification with oxoosmium complexes: structural and analytical aspects</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

XXXVII. Moderní elektrochemické metody. Sborník přednášek mezinárodní odborné konference

ISBN

978-80-905221-5-2

ISSN

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e-ISSN

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Number of pages

3

Pages from-to

"Č. 2017 (2017)"

Publisher name

Best servis

Place of publication

Ústí nad Labem

Event location

Jetřichovice

Event date

May 15, 2017

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000432424300012