Electrochemical Study of Osmium Tetroxide Comptests Reactivity to DNA Bearing Butylacrylate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00506547" target="_blank" >RIV/68081707:_____/18:00506547 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical Study of Osmium Tetroxide Comptests Reactivity to DNA Bearing Butylacrylate
Original language description
Coniplexes of osmium tetroside with nitrogen ligands (Os,L e.g.. with 2,2'-bipyridine (bpy) find application in redox labelling of DNA.. probing of DNA structure, and in studies of DNA interaction with other molecules Os,L preferentially react with pyrimidines in single strand DNA producing electroactive adducts Primary reaction site for Os,L is C=C double bond in pyrimidine nucleobases. In this contribution we introduce a new two-step technique of DNA modification with Os,bpy, consisting in enzymatic construdion or DNA beating butyl acrylate (BA) moieties attached to uracil or T-deaza adenine, followed by chemical modification of a reactive C=C double bond in BA residue.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XXXVIII. Moderní elektrochemické metody. Sborník přednášek
ISBN
978-80-905221-6-9
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
"Č. 2018 (2018)"
Publisher name
Best Servis
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 21, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000464596500015

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