All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00522155" target="_blank" >RIV/68081707:_____/19:00522155 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/19:00108159 RIV/00159816:_____/19:00072511

  • Result on the web

    <a href="http://jab.zsf.jcu.cz/doi/10.32725/jab.2019.018.pdf" target="_blank" >http://jab.zsf.jcu.cz/doi/10.32725/jab.2019.018.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.32725/jab.2019.018" target="_blank" >10.32725/jab.2019.018</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells

  • Original language description

    Embryonic stem (ES) cells are pluripotent cells widely used in cell therapy and tissue engineering. However, the broader clinical applications of ES cells are limited by their genomic instability and karyotypic abnormalities. Thus, understanding the mechanisms underlying ES cell karyotypic abnormalities is critical to optimizing their dinical use. In this study, we focused on proliferating human and mouse ES cells undergoing multipolar divisions. Specifically, we analyzed the frequency and outcomes of such divisions using a combination of time-lapse microscopy and cell tracking. This revealed that cells resulting from multipolar divisions were not only viable, but they also frequently underwent subsequent cell divisions. Our novel data also showed that in human and mouse ES cells, multipolar spindles allowed more robust escape from chromosome segregation control mechanisms than bipolar spindles. Considering the frequency of multipolar divisions in proliferating ES cells, it is conceivable that cell division errors underlie ES cell karyotypic instability.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Applied Biomedicine

  • ISSN

    1214-021X

  • e-ISSN

  • Volume of the periodical

    17

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    9

  • Pages from-to

    209-217

  • UT code for WoS article

    000510179600002

  • EID of the result in the Scopus database