Hepatocellular carcinoma: Gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00531024" target="_blank" >RIV/68081707:_____/20:00531024 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/20:00118001 RIV/00209805:_____/20:00078383 RIV/00216208:11140/20:10414123 RIV/00216208:11150/20:10414123 and 4 more
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0006295220301404?token=3D25CE828E97299D0C171631757962FCC4D8ACE1011E95D7E4EAAD1F87AC052C73877924C128524EA9A4E24110E4D01F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0006295220301404?token=3D25CE828E97299D0C171631757962FCC4D8ACE1011E95D7E4EAAD1F87AC052C73877924C128524EA9A4E24110E4D01F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bcp.2020.113912" target="_blank" >10.1016/j.bcp.2020.113912</a>
Alternative languages
Result language
angličtina
Original language name
Hepatocellular carcinoma: Gene expression profiling and regulation of xenobiotic-metabolizing cytochromes P450
Original language description
Hepatocellular carcinoma (HCC) remains a highly prevalent and deadly disease, being among the top causes of cancer-related deaths worldwide. Despite the fact that the liver is the major site of biotransformation, studies on drug metabolizing enzymes in HCC are scarce. It is known that malignant transformation of hepatocytes leads to a significant alteration of their metabolic functions and overall deregulation of gene expression. Advanced stages of the disease are thus frequently associated with liver failure, and severe alteration of drug metabolism. However, the impact of dysregulation of metabolic enzymes on therapeutic efficacy and toxicity in HCC patients is largely unknown.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/NV17-28231A" target="_blank" >NV17-28231A: Expression of biotransformation enzymes in primary liver cancers</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical Pharmacology
ISSN
0006-2952
e-ISSN
—
Volume of the periodical
177
Issue of the periodical within the volume
JUL 2020
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
113912
UT code for WoS article
000541248000005
EID of the result in the Scopus database
2-s2.0-85082649469