A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00542166" target="_blank" >RIV/68081707:_____/21:00542166 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2072-6694/13/1/18" target="_blank" >https://www.mdpi.com/2072-6694/13/1/18</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers13010018" target="_blank" >10.3390/cancers13010018</a>

Result language
angličtina
Original language name
A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?
Original language description
Radiation-induced double-strand breaks (DSBs) are the most toxic and most difficult to repair DNA lesions and are very heterogeneous. These characteristics place considerable demands on the selection of the most suitable repair mechanism at each individual damage site. Here, we review the current knowledge on this still enigmatic process and hypothesize that it critically involves the local chromatin architecture at the micro- and nanoscales, later manifested in the architecture of DSB repair foci (i.e., IRIFs).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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