Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00555923" target="_blank" >RIV/68081707:_____/22:00555923 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/nar/article/50/2/674/6501240?login=true" target="_blank" >https://academic.oup.com/nar/article/50/2/674/6501240?login=true</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkab1277" target="_blank" >10.1093/nar/gkab1277</a>
Alternative languages
Result language
angličtina
Original language name
Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles
Original language description
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive option. We have discovered that certain metallohelices-optically pure, self-assembling triple-stranded arrays of fully encapsulated Fe-act as nonviral DNA delivery vectors capable of mediating efficient gene transfection. They induce formation of globular DNA particles which protect the DNA from degradation by various restriction endonucleases, are of suitable size and electrostatic potential for efficient membrane transport and are successfully processed by cells. The activity is highly structure-dependent-compact and shorter metallohelix enantiomers are far less efficient than less compact and longer enantiomers.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA20-00735S" target="_blank" >GA20-00735S: Metallo-supramolecular helicates as DNA condensing agents and carriers for DNA delivery</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
1362-4962
Volume of the periodical
50
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
674-683
UT code for WoS article
000763001100011
EID of the result in the Scopus database
2-s2.0-85125004047