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Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00557781" target="_blank" >RIV/68081707:_____/22:00557781 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/22:00125545 RIV/00216305:26310/23:PU146867

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0300908421002947?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300908421002947?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.biochi.2021.12.006" target="_blank" >10.1016/j.biochi.2021.12.006</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conservation and over-representation of G-quadruplex sequences in regulatory regions of mitochondrial DNA across distinct taxonomic sub-groups

  • Original language description

    G-quadruplexes have important regulatory roles in the nuclear genome but their distribution and potential roles in mitochondrial DNA (mtDNA) are poorly understood. We analysed 11883 mtDNA sequences from 18 taxonomic sub-groups and identified their frequency and location within mtDNA. Large differences in both the frequency and number of putative quadruplex-forming sequences (PQS) were observed amongst all the organisms and PQS frequency was negatively correlated with an increase in evolutionary age. PQS were over-represented in the 30UTRs, D-loops, replication origins, and stem loops, indicating regulatory roles for quadruplexes in mtDNA. Variations of the G-quadruplex-forming sequence in the conserved sequence block II (CSBII) region of the human D-loop were conserved amongst other mammals, amphibians, birds, reptiles, and fishes. This D-loop PQS was conserved in the duplicated control regions of some birds and reptiles, indicating its importance to mitochondrial function. The guanine tracts in these PQS also displayed significant length heterogeneity and the length of these guanine tracts were generally longest in bird mtDNA. This information provides further insights into how G4s may contribute to the regulation and function of mtDNA and acts as a database of information for future studies investigating mitochondrial G4s in organisms other than humans. (C)& nbsp, 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/GA18-15548S" target="_blank" >GA18-15548S: Comparative study of DNA interacting properties of the tumor suppressor p53 protein isoforms</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimie

  • ISSN

    0300-9084

  • e-ISSN

    1638-6183

  • Volume of the periodical

    194

  • Issue of the periodical within the volume

    MAR 2022

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    7

  • Pages from-to

    28-34

  • UT code for WoS article

    000795141500004

  • EID of the result in the Scopus database

    2-s2.0-85122487113