Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00558373" target="_blank" >RIV/68081707:_____/22:00558373 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/22:PU144986 RIV/00216224:14310/22:00126190
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2qm00200k" target="_blank" >10.1039/d2qm00200k</a>

Result language
angličtina
Original language name
Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers
Original language description
The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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