Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00560039" target="_blank" >RIV/68081707:_____/22:00560039 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/22:73614883
Result on the web
<a href="https://www.hindawi.com/journals/bca/2022/3095749/" target="_blank" >https://www.hindawi.com/journals/bca/2022/3095749/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2022/3095749" target="_blank" >10.1155/2022/3095749</a>
Alternative languages
Result language
angličtina
Original language name
Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells
Original language description
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking selectivity to cancer cells compared to noncancerous human fibroblasts. The data reveal that the complex induces ferroptosis in rhabdomyosarcoma cells, likely due to interfering with iron metabolism. Importantly, it can kill both bulk and stem rhabdomyosarcoma cells. To the best of our knowledge, this is the first compound based on metal other than Fe capable of inducing ferroptosis in cancer cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA21-27514S" target="_blank" >GA21-27514S: Metal-based compounds for enhanced cancer immunotherapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioinorganic Chemistry and Applications
ISSN
1565-3633
e-ISSN
1687-479X
Volume of the periodical
2022
Issue of the periodical within the volume
APR 23 2022
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
3095749
UT code for WoS article
000832991500002
EID of the result in the Scopus database
2-s2.0-85129510384