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Synthesis and evaluation of 2,9-disubstituted-1,10-phenanthroline derivatives as G-quadruplex binders

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F22%3A00563244" target="_blank" >RIV/68081707:_____/22:00563244 - isvavai.cz</a>

  • Result on the web

    <a href="https://reader.elsevier.com/reader/sd/pii/S0968089622003649?token=A4EAFEEB1A2D211C650C572D440F273643EE887CF8238E8B72F14E24D6A6E20A00CA5CE417490443521225405C2455A0&originRegion=eu-west-1&originCreation=20221108091428" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0968089622003649?token=A4EAFEEB1A2D211C650C572D440F273643EE887CF8238E8B72F14E24D6A6E20A00CA5CE417490443521225405C2455A0&originRegion=eu-west-1&originCreation=20221108091428</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bmc.2022.116971" target="_blank" >10.1016/j.bmc.2022.116971</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and evaluation of 2,9-disubstituted-1,10-phenanthroline derivatives as G-quadruplex binders

  • Original language description

    G-quadruplex (G4) structures are non-canonical DNA/RNA secondary structures able to form within guanine rich nucleic acids sequences. They are present in several regions of the human genome including gene promoters, untranslated sequences, and telomeres. Due to their biological relevance G4 structures are considered important drug targets, in particular for anticancer therapies, leading to the development of G4 stabilizing small molecules. Telomeric regions have received special attention in this field since they can fold into several distinct intramolecular G-quadruplexes topologies. Herein, we report the synthesis of 2,9-disubstituted-1,10-phenanthroline derivatives and their ability to stabilize different intramolecular telomeric G4 sequences.We evaluated ligand-induced stabilization, selectivity and specificity of ligands using Fo spacing diaeresis rster Resonance Energy Transfer (FRET) melting experiments and circular dichroism (CD). In addition, we assessed the cytotoxicity of ligands against two cancer cell lines (A549 and H1299) and one healthy cell line (NHDF).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutic targets.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bioorganic & Medicinal Chemistry

  • ISSN

    0968-0896

  • e-ISSN

    1464-3391

  • Volume of the periodical

    73

  • Issue of the periodical within the volume

    NOV 1 2022

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    116971

  • UT code for WoS article

    000868425800001

  • EID of the result in the Scopus database

    2-s2.0-85139346147