An in vitro model that mimics the foreign body response in the peritoneum: Study of the bioadhesive properties of HA-based materials
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00571536" target="_blank" >RIV/68081707:_____/23:00571536 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00131094 RIV/00216208:11120/23:43925171 RIV/00159816:_____/23:00079640
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861723001650?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861723001650?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2023.120701" target="_blank" >10.1016/j.carbpol.2023.120701</a>
Alternative languages
Result language
angličtina
Original language name
An in vitro model that mimics the foreign body response in the peritoneum: Study of the bioadhesive properties of HA-based materials
Original language description
A cascade of reactions known as the foreign body response (FBR) follows the implantation of biomaterials leading to the formation of a fibrotic capsule around the implant and subsequent health complications. The severity of the FBR is driven mostly by the physicochemical characteristics of implanted material, the method and place of implantation, and the degree of immune system activation. Here we present an in vitro model for assessing new materials with respect to their potential to induce a FBR in the peritoneum. The model is based on evaluating protein sorption and cell adhesion on the implanted material. We tested our model on the free-standing films prepared from hyaluronan derivatives with different hydrophobicity, swelling ratio, and rate of solubilization. The proteomic analysis of films incubated in the mouse peritoneum showed that the presence of fibrinogen was driving the cell adhesion. Neither the film surface hydrophobicity/hydrophilicity nor the quantity of adsorbed proteins were decisive for the induction of the long-term cell adhesion leading to the FBR, while the dissolution rate of the material proved to be a crucial factor. Our model thus helps determine the probability of a FBR to materials implanted in the peritoneum while limiting the need for in vivo animal testing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/EF16_026%2F0008451" target="_blank" >EF16_026/0008451: Engineering of new biomaterials and biopharmaceuticals for the diagnosis and treatment of the cerebrovascular and neurodegenerative diseases</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Polymers
ISSN
0144-8617
e-ISSN
1879-1344
Volume of the periodical
310
Issue of the periodical within the volume
JUN 15 2023
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
120701
UT code for WoS article
000944783900001
EID of the result in the Scopus database
2-s2.0-85148547615