Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00581799" target="_blank" >RIV/68081707:_____/23:00581799 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00581799 RIV/00216224:14310/23:00130574 RIV/00216208:11110/23:10465338 RIV/00159816:_____/23:00079652
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0144861723003454?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0144861723003454?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carbpol.2023.120880" target="_blank" >10.1016/j.carbpol.2023.120880</a>

Result language
angličtina
Original language name
Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid
Original language description
The ability of hyaluronan as a dietary supplement to increase skin moisture and relieve knee pain has been demonstrated in several clinical studies. To understand the mechanism of action, determining hyaluronan's bioavailability and in vivo fate is crucial. Here, we used 13C-hyaluronan combined with LC-MS analysis to compare the absorption and metabolism of oral hyaluronan in germ-free and conventional wild-type mice. The presence of Bacteroides spp. in the gut was crucial for hyaluronan absorption. Specific microorganisms cleave hyaluronan into unsaturated oligosaccharides (<3 kDa) which are partially absorbed through the intestinal wall. The remaining hyaluronan fragments are metabolized into short-chain fatty acids, which are only metabolites available to the host. The poor bioavailability (similar to 0.2 %) of oral hyaluronan indicates that the mechanism of action is the result of the systematic regulatory function of hyaluronan or its metabolites rather than the direct effects of hyaluronan at distal sites of action (skin, joints).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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