Biocompatibility of colloidal polypyrrole

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00583313" target="_blank" >RIV/68081707:_____/23:00583313 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28110/23:63570158 RIV/70883521:28610/23:63570158
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfb.2023.113605" target="_blank" >10.1016/j.colsurfb.2023.113605</a>

Result language
angličtina
Original language name
Biocompatibility of colloidal polypyrrole
Original language description
The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/GA23-07425S" target="_blank" >GA23-07425S: Anisotropic and Electro-Conducting Biomaterials</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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