Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00600741" target="_blank" >RIV/68081707:_____/24:00600741 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/24:00135565

Result on the web

<a href="https://www.nature.com/articles/s42003-024-05855-w" target="_blank" >https://www.nature.com/articles/s42003-024-05855-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s42003-024-05855-w" target="_blank" >10.1038/s42003-024-05855-w</a>

Result language

angličtina

Original language name

Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity

Original language description

Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GM22-20303M" target="_blank" >GM22-20303M: Deciphering Origins of DNA replication in genome integrity</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Communications Biology

ISSN

2399-3642

e-ISSN

2399-3642

Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

167

UT code for WoS article

001159273400002

EID of the result in the Scopus database

2-s2.0-85184794567