Distinct functions of human RecQ helicases during DNA replication
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00487323" target="_blank" >RIV/68378050:_____/17:00487323 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bpc.2016.11.005" target="_blank" >http://dx.doi.org/10.1016/j.bpc.2016.11.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bpc.2016.11.005" target="_blank" >10.1016/j.bpc.2016.11.005</a>
Alternative languages
Result language
angličtina
Original language name
Distinct functions of human RecQ helicases during DNA replication
Original language description
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefore it is tightly controlled and coordinated with processes that maintain genomic stability. Human RecQ helicases are among the most important factors involved in the maintenance of replication fork integrity, especially under conditions of replication stress. RecQ helicases promote recovery of replication forks being stalled due to different replication roadblocks of either exogenous or endogenous source. They prevent generation of aberrant replication fork structures and replication fork collapse, and are involved in proper checkpoint signaling. The essential role of human RecQ helicases in the genome maintenance during DNA replication is underlined by association of defects in their function with cancer predisposition. (C) 2016 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biophysical Chemistry
ISSN
0301-4622
e-ISSN
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Volume of the periodical
225
Issue of the periodical within the volume
červen
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
20-26
UT code for WoS article
000405048400005
EID of the result in the Scopus database
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