Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00064997" target="_blank" >RIV/00159816:_____/16:00064997 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/16:00088199

Result on the web

<a href="http://dx.doi.org/10.1101/gad.276204.115" target="_blank" >http://dx.doi.org/10.1101/gad.276204.115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1101/gad.276204.115" target="_blank" >10.1101/gad.276204.115</a>

Result language

angličtina

Original language name

Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

Original language description

Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1 Delta mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes &amp; Development

ISSN

0890-9369

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

18

Pages from-to

700-717

UT code for WoS article

000371974500008

EID of the result in the Scopus database

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