G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00600915" target="_blank" >RIV/68081707:_____/24:00600915 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26310/24:PU151738

Result on the web

<a href="https://academic.oup.com/nargab/article/6/2/lqae060/7685155?login=true" target="_blank" >https://academic.oup.com/nargab/article/6/2/lqae060/7685155?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nargab/lqae060" target="_blank" >10.1093/nargab/lqae060</a>

Result language

angličtina

Original language name

G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes

Original language description

Current methods of processing archaeological samples combined with advances in sequencing methods lead to disclosure of a large part of H. neanderthalensis and Denisovans genetic information. It is hardly surprising that the genome variability between modern humans, Denisovans and H. neanderthalensis is relatively limited. Genomic studies may provide insight on the metabolism of extinct human species or lineages. Detailed analysis of G-quadruplex sequences in H. neanderthalensis and Denisovans mitochondrial DNA showed us interesting features. Relatively similar patterns in mitochondrial DNA are found compared to modern humans, with one notable exception for H. neanderthalensis. An interesting difference between H. neanderthalensis and H. sapiens corresponds to a motif found in the D-loop region of mtDNA, which is responsible for mitochondrial DNA replication. This area is directly responsible for the number of mitochondria and consequently for the efficient energy metabolism of cell. H. neanderthalensis harbor a long uninterrupted run of guanines in this region, which may cause problems for replication, in contrast with H. sapiens, for which this run is generally shorter and interrupted. One may propose that the predominant H. sapiens motif provided a selective advantage for modern humans regarding mtDNA replication and function.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA22-21903S" target="_blank" >GA22-21903S: Local DNA structures and their role in mutant p53 protein function in human tumours</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NAR Genomics and Bioinformatics

ISSN

2631-9268

e-ISSN

2631-9268

Volume of the periodical

6

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

lqae060

UT code for WoS article

001234844000001

EID of the result in the Scopus database

2-s2.0-85194948258