A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00602572" target="_blank" >RIV/68081707:_____/24:00602572 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137823 RIV/00159816:_____/24:00081427

Result on the web

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314079" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314079</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0314079" target="_blank" >10.1371/journal.pone.0314079</a>

Result language

angličtina

Original language name

A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction

Original language description

Collaterals improve recanalization in acute ischemic stroke patients treated with intravenous thrombolysis, but the mechanisms are poorly understood. To investigate it, an in vitro flow model of the middle cerebral artery was developed with or without collaterals. An occlusion was achieved using human blood clots. Recanalization time, thrombolysis (clot length decrease and red blood cell (RBC) release), pressure gradient across the clot and clot compaction were measured. Results showed that with or without collateral alteplase-treated RBC dominant clots showed recanalization time 98 +/- 23 min vs 130 +/- 35 min (difference 32 min, 95% CI6-58 min), relative clot reduction 31.8 +/- 14.9% vs 30.3 +/- 13.2% (difference 1.5%, 95% CI 10.4-13.4%) and RBC release 0.30 +/- 0.07 vs 0.27 +/- 0.09 (difference 0.03, 95% CI 0.04-0.10). Similar results were observed with fibrin-dominant clots. In RBC dominant clots, the presence vs absence of collateral caused different pressure gradients across the clot 0.41 +/- 0.09 vs 0.70 +/- 0.09 mmHg (difference 0.29 mmHg, 95% CI0.17-0.41 mmHg), and caused the reduction of initial clot compaction by 5%. These findings align with observations in patients, where collaterals shortened recanalization time. However, collaterals did not increase thrombolysis. Instead, they decreased the pressure gradient across the clot, resulting in less clot compaction and easier distal displacement of the clot.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30502 - Other medical science

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

1932-6203

Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

e0314079

UT code for WoS article

001360846500006

EID of the result in the Scopus database

2-s2.0-85209911131