Complex Biophysical and Computational Analyses of G-Quadruplex Ligands: The Porphyrin Stacks Back
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00602933" target="_blank" >RIV/68081707:_____/24:00602933 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26310/24:PU152546
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202402600" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202402600</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.202402600" target="_blank" >10.1002/chem.202402600</a>
Alternative languages
Result language
angličtina
Original language name
Complex Biophysical and Computational Analyses of G-Quadruplex Ligands: The Porphyrin Stacks Back
Original language description
G-quadruplexes (G4 s), as non-canonical DNA structures, attract a great deal of research interest in the molecular biology as well as in the material science fields. The use of small molecules as ligands for G-quadruplexes has emerged as a tool to regulate gene expression and telomeres maintenance. Meso-tetrakis-(N-methyl-4-pyridyl) porphyrin (TMPyP4) was shown as one of the first ligands for G-quadruplexes and it is still widely used. We report an investigation comprising molecular docking and dynamics, synthesis and multiple spectroscopic and spectrometric determinations on simple cationic porphyrins and their interaction with different DNA sequences. This study enabled the synthesis of tetracationic porphyrin derivatives that exhibited binding and stabilizing capacity against G-quadruplex structures, the detailed characterization has shown that the presence of amide groups at the periphery improves selectivity for parallel G4 s binding over other structures. Taking into account the ease of synthesis, 5,10,15,20-tetrakis-(1-acetamido-4-pyridyl) porphyrin bromide could be considered a better alternative to TMPyP4 in studies involving G4 binding.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry - A European Journal
ISSN
0947-6539
e-ISSN
1521-3765
Volume of the periodical
30
Issue of the periodical within the volume
69
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
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UT code for WoS article
001357373800001
EID of the result in the Scopus database
2-s2.0-85208132591