N4-acetylcytidine and other RNA modifications in epitranscriptome: insight into DNA repair and cancer development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00618993" target="_blank" >RIV/68081707:_____/25:00618993 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/17501911.2025.2473308" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/17501911.2025.2473308</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/17501911.2025.2473308" target="_blank" >10.1080/17501911.2025.2473308</a>
Alternative languages
Result language
angličtina
Original language name
N4-acetylcytidine and other RNA modifications in epitranscriptome: insight into DNA repair and cancer development
Original language description
N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that plays a crucial role in the epitranscriptome, influencing gene expression and cellular function. This modification occurs at the cytosine base, where an acetyl group is installed to the nitrogen at the 4th position (N4). This co-transcription modification affects RNA stability, RNA structure, and translation efficiency. Recent studies have uncovered a potential link between RNA modifications and DNA repair mechanisms, suggesting that ac4C-modified or methylated RNAs may interact with factors involved in DNA repair pathways, thus, influencing the cellular response to DNA damage. Dysregulation of modified RNAs, including ac4C RNA, has been implicated in cancer development, where aberrant levels of these RNAs may contribute to oncogenic transformation by altering genome stability and the expression of key genes regulating cell proliferation, cell cycle progression, and apoptosis. Understanding the dynamics of modified RNAs offers promising insights into the role of epitranscriptome in DNA repair processes and cancer treatment.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/LUAUS25085" target="_blank" >LUAUS25085: Impacts of Steroid Hormones on RNA Modifications in an Irradiated Genome</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epigenomics
ISSN
1750-1911
e-ISSN
1750-192X
Volume of the periodical
17
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
411-422
UT code for WoS article
001437553900001
EID of the result in the Scopus database
2-s2.0-86000279421