One-step fabrication of chitosan/dialdehyde cellulose/polypyrrole composite nanofibers with antibacterial, antioxidant, and immunomodulatory effects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00635565" target="_blank" >RIV/68081707:_____/25:00635565 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28110/25:63594681 RIV/70883521:28610/25:63594681
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0141813025026571?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813025026571?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.142105" target="_blank" >10.1016/j.ijbiomac.2025.142105</a>
Alternative languages
Result language
angličtina
Original language name
One-step fabrication of chitosan/dialdehyde cellulose/polypyrrole composite nanofibers with antibacterial, antioxidant, and immunomodulatory effects
Original language description
The study introduces a novel method for fabricating crosslinked chitosan/polypyrrole (PPy) composite nano- fibers with covalently anchored PPy. Crosslinking is achieved already during electrospinning by using dialdehyde cellulose (DAC) as a dual-functioning reagent able to simultaneously crosslink chitosan nanofibers and covalently tether PPy nanoparticles by a newly discovered aldol condensation reaction. The presented method eliminates the need for postprocessing steps. It reduces the environmental impact by avoiding toxic organic chemicals while preventing PPy leaching and improving prepared composite nanofibers' mechanical and biological properties. A direct comparison to neat chitosan nanofibres was performed to demonstrate the superiority of prepared composites. The resulting crosslinked CHIT_DAC_PPy composite nanofibers have increased tensile strength, improved stability at low pH, conductivity up to 11 mS/cm, and higher swelling compared to neat CHIT nanofibers. They also possess significantly enhanced antibacterial activity against gram-positive S. aureus, higher antioxidant activity, increased immunomodulatory effects, and substantially higher acceleration of wound healing in vitro. CHIT_DAC_PPy nanofibrous composite thus shows significant potential for fabricating advanced wound dressings.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA24-11534S" target="_blank" >GA24-11534S: Conductive (bio)polymer composites with covalently anchored polypyrrole for biomedical applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biological Macromolecules
ISSN
0141-8130
e-ISSN
1879-0003
Volume of the periodical
308
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
142105
UT code for WoS article
001457068600001
EID of the result in the Scopus database
2-s2.0-105000702121