Injectable anti-inflammatory chitosan/polypyrrole composite hydrogels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63588558" target="_blank" >RIV/70883521:28610/24:63588558 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Injectable anti-inflammatory chitosan/polypyrrole composite hydrogels
Original language description
Injectable composite hydrogels based on conductive polymers hold significant promise for the development of various biomaterials. In this study, we introduce a novel method for preparing composite hydrogels with covalently anchored polypyrrole (PPy) nanoparticles. The hydrogel matrix consists of partially re-acetylated chitosan, crosslinked using cellulose dialdehyde (DAC), which also serves for the covalent anchoring of PPy through aldol condensation. Dynamic covalent bonds formed between chitosan and DAC are disrupted upon application of stimuli, such as pressure or shear, and hydrogel liquifies, allowing direct injectability of the composite. Covalently anchored 40 nm PPy nanoparticles improve the mechanical properties of the composite and provide various beneficial biological effects. ln vitro studies confirmed that prepared composite hydrogels are non-cytotoxic, non-irritating, and antibacterial. They also accelerate wound healing, possess strong antioxidant properties, and modulate the response of macrophages towards non-inflammatory action. Overall, developed systems are promising candidates for the preparation of injectable anti-inflammatory biomaterials. ln vivo tests are currently underway.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
<a href="/en/project/GA24-11534S" target="_blank" >GA24-11534S: Conductive (bio)polymer composites with covalently anchored polypyrrole for biomedical applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů