mGem: Noncanonical nucleic acid structures-powerful but neglected antiviral targets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00642112" target="_blank" >RIV/68081707:_____/25:00642112 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17310/25:A2603CYP
Result on the web
<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12607565/" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC12607565/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/mbio.02730-25" target="_blank" >10.1128/mbio.02730-25</a>

Result language
angličtina
Original language name
mGem: Noncanonical nucleic acid structures-powerful but neglected antiviral targets
Original language description
This perspective highlights the emerging significance of noncanonical nucleic acid structures-such as G-quadruplexes, Z-DNA/Z-RNA, and cruciforms-in viral genomes. Once considered structural oddities, these motifs are now recognized as critical regulators of viral replication, transcription, genome stability, and host-pathogen interactions. Despite mounting evidence of their functional relevance and therapeutic potential, these structures remain largely overlooked in virology and antiviral drug development. Their unique conformations offer highly specific molecular targets, with several small molecules already demonstrating the ability to modulate viral gene expression by stabilizing or destabilizing these motifs. The persistent underestimation of non-B DNA/RNA structures represents a missed opportunity in the fight against viral diseases. By synthesizing recent discoveries and emphasizing their biological and pharmacological promise, we aim to elevate awareness and catalyze interdisciplinary research. Harnessing the structural diversity of viral genomes could unlock novel antiviral strategies with high specificity and minimal off-target effects.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology

Project
<a href="/en/project/EF15_003%2F0000477" target="_blank" >EF15_003/0000477: Structural gymnastics of nucleic acids: from molecular principles through biological functions to therapeutic targets.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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