Capillary electrophoresis in the analysis of biologically important thiols

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F17%3A00464032" target="_blank" >RIV/68081715:_____/17:00464032 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/17:00094683

Result on the web

<a href="http://dx.doi.org/10.1002/elps.201600354" target="_blank" >http://dx.doi.org/10.1002/elps.201600354</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201600354" target="_blank" >10.1002/elps.201600354</a>

Result language

angličtina

Original language name

Capillary electrophoresis in the analysis of biologically important thiols

Original language description

In this review article, CE methods for analysis of biologically important thiols are overviewed. The article covers the period from the previously published comprehensive review in 2004 until mid-2016, with emphasis on various detectionmodes, novel approaches for sample preconcentration, and applications in clinical practice. The most commonly used detection methods, such as conductometry or absorbance detection, although universally applicable and available in most commercial instruments have low sensitivity and have only limited use in thiol analysis. Amperometric andMS detection are more sensitive and have their steady place in thiol analysis, although the mainstay remains CE with LIF detection, reaching nanomolar concentration sensitivities for most of the thiols. Novel probes for CE-LIF have been developed and tested. The preconcentration approaches using modified gold nanoparticles reaching excellent sensitivities in the picomolar range and various sample stacking methods are also reviewed. Finally, significant clinical applications of the developed methods are discussed with critical insights into the future of CE analysis of thiols.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

20

Pages from-to

203-222

UT code for WoS article

000392422100013

EID of the result in the Scopus database

2-s2.0-84995387151