Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F17%3A00480406" target="_blank" >RIV/68081731:_____/17:00480406 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/17:00094662 RIV/00216305:26620/17:PU123018
Result on the web
<a href="http://dx.doi.org/10.1155/2017/7859289" target="_blank" >http://dx.doi.org/10.1155/2017/7859289</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2017/7859289" target="_blank" >10.1155/2017/7859289</a>

Result language
angličtina
Original language name
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Original language description
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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