Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F19%3A00508988" target="_blank" >RIV/68081731:_____/19:00508988 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/19:00508988 RIV/00216224:14110/19:00110205 RIV/62157124:16370/19:43877806

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1734114019300714?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1734114019300714?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pharep.2019.04.020" target="_blank" >10.1016/j.pharep.2019.04.020</a>

Result language

angličtina

Original language name

Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

Original language description

Background: Olanzapine is a frequently used atypical antipsychotic drug known to exert structural brain alterations in animals. This study investigated whether chronic olanzapine exposure alters regional blood brain perfusion assessed by Arterial Spin Labelling (ASL) magnetic resonance imaging (MRI) in a validated model of olanzapine-induced metabolic disturbances. An effect of acute olanzapine exposure on brain perfusion was also assessed for comparison. Methods: Adult Sprague-Dawley female rats were treated by intramuscular depot olanzapine injections (100 mg/kg every 14 days) or vehicle for 8 weeks. ASL scanning was performed on a 9.4 T Bruker BioSpec 94/30USR scanner under isoflurane anesthesia. Serum samples were used to assay leptin and TNF-α level while brains were sliced for histology. Another group received only one non-depot intraperitoneal dose of olanzapine (7 mg/kg) during MRI scanning, thus exposing its acute effect on brain perfusion. Results: Both acute and chronic dosing of olanzapine resulted in decreased perfusion in the sensorimotor cortex, while no effect was observed in the piriform cortex or hippocampus. Furthermore, in the chronically treated group decreased cortex volume was observed. Chronic olanzapine dosing led to increased body weight, adipose tissue mass and leptin level, confirming its expected metabolic effects. Conclusion: This study demonstrates region-specific decreases in blood perfusion associated with olanzapine exposure present already after the first dose. These findings extend our understanding of olanzapine-induced functional and structural brain changes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological Reports

ISSN

1734-1140

e-ISSN

—

Volume of the periodical

71

Issue of the periodical within the volume

5

Country of publishing house

PL - POLAND

Number of pages

9

Pages from-to

839-847

UT code for WoS article

000490122700013

EID of the result in the Scopus database

2-s2.0-85070099227