Arterial stiffness and haemodynamic regulation in adolescent anorexia nervosa versus obesity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F20%3A00525075" target="_blank" >RIV/68081731:_____/20:00525075 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/20:00072946
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/31163115/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31163115/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1139/apnm-2018-0867" target="_blank" >10.1139/apnm-2018-0867</a>
Alternative languages
Result language
angličtina
Original language name
Arterial stiffness and haemodynamic regulation in adolescent anorexia nervosa versus obesity
Original language description
Cardiovascular complications contribute to higher morbidity and mortality in patients with anorexia nervosa. We aimed to study biomarkers of cardiovascular risk in anorexic, normal-weight, and obese adolescents with focus on complex cardiovascular autonomic regulation and early arteriosclerotic damage. We examined 20 adolescent girls with anorexia nervosa, 20 obese girls, and 20 healthy normal-weight controls. Collected data: body composition analysis, 5 min recordings of R-R intervals and beat-to-beat blood pressure (BP), and arterial stiffness evaluated using cardio-ankle vascular index (CAVI). Evaluated parameters: beat-to-beat heart rate and BP variability, haemodynamic parameters (total peripheral resistance (TPR) cardiac output), CAVI, and anthropometric indices, including novel body roundness index (BRI). Adolescents with anorexia nervosa had increased CAVI associated with lower arterial constriction indexed by low-frequency band of BP variability compared with normal-weight peers (p = 0.03, p = 0.04, respectively) and obese adolescents (p < 0.01, p = 0.01, respectively). After normalization of CAVI and TPR by BRI, the relationship between CAVI and TPR was significant for all groups with the highest slope in the anorexia nervosa group (R-2 = 0.724, p < 0.01). This is the first study revealing early arteriosclerotic damage in anorexic girls with increased CAVI. Complex analysis of cardiovascular autonomic regulation, and early arteriosclerotic, hemodynamic, and anthropometric changes in spectrum anorexia nervosa, normal weight, and obesity could help to understand the mechanisms of increased cardiovascular risk in malnutrition.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme
ISSN
1715-5312
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
1
Country of publishing house
CA - CANADA
Number of pages
10
Pages from-to
81-90
UT code for WoS article
000505671200010
EID of the result in the Scopus database
2-s2.0-85073802539