Computational image enhancement of multimode fibre-based holographic endo-microscopy: harnessing the muddy modes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00548489" target="_blank" >RIV/68081731:_____/21:00548489 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/21:PU142228
Result on the web
<a href="https://www.osapublishing.org/oe/fulltext.cfm?uri=oe-29-23-38206&id=464465" target="_blank" >https://www.osapublishing.org/oe/fulltext.cfm?uri=oe-29-23-38206&id=464465</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1364/OE.434848" target="_blank" >10.1364/OE.434848</a>

Result language
angličtina
Original language name
Computational image enhancement of multimode fibre-based holographic endo-microscopy: harnessing the muddy modes
Original language description
In imaging geometries, which employ wavefront-shaping to control the light transport through a multi-mode optical fibre (MMF), this terminal hair-thin optical component acts as a minimally invasive objective lens, enabling high resolution laser-scanning fluorescence microscopy inside living tissues at depths hardly accessible by any other light-based technique. Even in the most advanced systems, the diffraction-limited foci scanning the object across the focal plane are contaminated by a stray optical signal carrying typically few tens of % of the total optical power. The stray illumination takes the shape of a randomised but reproducible speckle, and is unique for each position of the focus. We experimentally demonstrate that the performance of imaging a fluorescent object can be significantly improved, when resulting images are computationally post-processed, utilising records of intensities of all speckle-contaminated foci used in the imaging procedure. We present two algorithms based on a regularised iterative inversion and regularised direct pseudo-inversion respectively which lead to enhancement of the image contrast and resolution.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10306 - Optics (including laser optics and quantum optics)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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