Direct Electrical Stimulation of the Human Brain Has Inverse Effects on the Theta and Gamma Neural Activities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00549292" target="_blank" >RIV/68081731:_____/21:00549292 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00075020
Result on the web
<a href="https://ieeexplore.ieee.org/document/9437700" target="_blank" >https://ieeexplore.ieee.org/document/9437700</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/TBME.2021.3082320" target="_blank" >10.1109/TBME.2021.3082320</a>
Alternative languages
Result language
angličtina
Original language name
Direct Electrical Stimulation of the Human Brain Has Inverse Effects on the Theta and Gamma Neural Activities
Original language description
Objective: Our goal was to analyze the electrophysiological response to direct electrical stimulation (DES) systematically applied at a wide range of parameters and anatomical sites, with particular focus on neural activities associated with memory and cognition. Methods: We used a large set of intracranial EEG (iEEG) recordings with DES from 45 subjects with electrodes implanted both subdurally on the cortical surface and subcortically into the brain parenchyma. Subjects were stimulated in blocks of alternating frequency and amplitude parameters during quiet wakefulness. Results: Stimulating at different frequencies and amplitudes of electric current revealed a persistent pattern of response in the slow and the fast neural activities. In particular, amplification of the theta (4-7 Hz) and attenuation of the gamma (29-52 Hz) power-in-band was observed with increasing the stimulation parameters. This opposite effect on the low and high frequency bands was found across a network of selected local and distal sites proportionally to the proximity and magnitude of the electric current. Power increase in the theta and decrease in the gamma band was driven by the total electric charge delivered with either increasing the frequency or amplitude of the stimulation current. This inverse effect on the theta and gamma activities was consistently observed in response to different stimulation frequencies and amplitudes. Conclusion: Our results suggest a uniform DES effect of amplifying theta and suppressing gamma neural activities in the human brain. Significance: These findings reveal the utility of simple power-in-band features for understanding and optimizing the effects of electrical stimulation on brain functions.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20601 - Medical engineering
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IEEE Transactions on Biomedical Engineering
ISSN
0018-9294
e-ISSN
1558-2531
Volume of the periodical
68
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
3701-3712
UT code for WoS article
000720518600028
EID of the result in the Scopus database
2-s2.0-85107208997