All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Direct Electrical Stimulation of the Human Brain Has Inverse Effects on the Theta and Gamma Neural Activities

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00549292" target="_blank" >RIV/68081731:_____/21:00549292 - isvavai.cz</a>

  • Alternative codes found

    RIV/00159816:_____/21:00075020

  • Result on the web

    <a href="https://ieeexplore.ieee.org/document/9437700" target="_blank" >https://ieeexplore.ieee.org/document/9437700</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1109/TBME.2021.3082320" target="_blank" >10.1109/TBME.2021.3082320</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Direct Electrical Stimulation of the Human Brain Has Inverse Effects on the Theta and Gamma Neural Activities

  • Original language description

    Objective: Our goal was to analyze the electrophysiological response to direct electrical stimulation (DES) systematically applied at a wide range of parameters and anatomical sites, with particular focus on neural activities associated with memory and cognition. Methods: We used a large set of intracranial EEG (iEEG) recordings with DES from 45 subjects with electrodes implanted both subdurally on the cortical surface and subcortically into the brain parenchyma. Subjects were stimulated in blocks of alternating frequency and amplitude parameters during quiet wakefulness. Results: Stimulating at different frequencies and amplitudes of electric current revealed a persistent pattern of response in the slow and the fast neural activities. In particular, amplification of the theta (4-7 Hz) and attenuation of the gamma (29-52 Hz) power-in-band was observed with increasing the stimulation parameters. This opposite effect on the low and high frequency bands was found across a network of selected local and distal sites proportionally to the proximity and magnitude of the electric current. Power increase in the theta and decrease in the gamma band was driven by the total electric charge delivered with either increasing the frequency or amplitude of the stimulation current. This inverse effect on the theta and gamma activities was consistently observed in response to different stimulation frequencies and amplitudes. Conclusion: Our results suggest a uniform DES effect of amplifying theta and suppressing gamma neural activities in the human brain. Significance: These findings reveal the utility of simple power-in-band features for understanding and optimizing the effects of electrical stimulation on brain functions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    IEEE Transactions on Biomedical Engineering

  • ISSN

    0018-9294

  • e-ISSN

    1558-2531

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    3701-3712

  • UT code for WoS article

    000720518600028

  • EID of the result in the Scopus database

    2-s2.0-85107208997