Hybrid multimode - multicore fibre based holographic endoscope for deep-tissue neurophotonics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F22%3A00564722" target="_blank" >RIV/68081731:_____/22:00564722 - isvavai.cz</a>
Result on the web
<a href="https://www.light-am.com/article/doi/10.37188/lam.2022.029" target="_blank" >https://www.light-am.com/article/doi/10.37188/lam.2022.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37188/lam.2022.029" target="_blank" >10.37188/lam.2022.029</a>
Alternative languages
Result language
angličtina
Original language name
Hybrid multimode - multicore fibre based holographic endoscope for deep-tissue neurophotonics
Original language description
n-vivo microendoscopy in animal models became a groundbreaking technique in neuroscience that rapidly expands our understanding of the brain. Emerging hair-thin endoscopes based on multimode fibres are now opening up the prospect of ultra-minimally invasive neuroimaging of deeply located brain structures. Complementing these advancements with methods of functional imaging and optogenetics, as well as extending its applicability to awake and motile animals constitute the most pressing challenges for this technology. Here we demonstrate a novel fibre design capable of both, high-resolution imaging in immobilised animals and bending-resilient optical addressing of neurons in motile animals. The optimised refractive index profile and the probe structure allowed reaching a spatial resolution of 2 μm across a 230 μm field of view for the initial layout of the fibre. Simultaneously, the fibre exhibits negligible cross-talk between individual inner-cores during fibre deformation. This work provides a technological solution for imaging-assisted spatially selective photo-activation and activity monitoring in awake and freely moving animal models.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10306 - Optics (including laser optics and quantum optics)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000476" target="_blank" >EF15_003/0000476: Holographic endoscopy for in vivo applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Light: Advanced Manufacturing
ISSN
2689-9620
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
3
Country of publishing house
CN - CHINA
Number of pages
9
Pages from-to
29
UT code for WoS article
001350219300001
EID of the result in the Scopus database
2-s2.0-85148611611