Reduction of Ultra-High-Frequency ECG Components Following Sodium Channel Blockade by Propafenone: Evidence for Their Electrophysiological Origin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00648272" target="_blank" >RIV/68081731:_____/25:00648272 - isvavai.cz</a>
Result on the web
<a href="https://cinc.org/archives/2025/pdf/CinC2025-277.pdf" target="_blank" >https://cinc.org/archives/2025/pdf/CinC2025-277.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.22489/CinC.2025.277" target="_blank" >10.22489/CinC.2025.277</a>

Result language
angličtina
Original language name
Reduction of Ultra-High-Frequency ECG Components Following Sodium Channel Blockade by Propafenone: Evidence for Their Electrophysiological Origin
Original language description
Background: Ultra-high-frequency (UHF) ECG is a non-invasive method for assessing ventricular electrical dyssynchrony. The origin of UHF components in ECG remains uncertain. It has been hypothesized that UHF components arise from rapid changes in membrane voltage during sodium channel opening. This study aimed to evaluate changes in UHF components after the administration of propafenone, a sodium channel blocker. Method: We analyzed data from 12 patients. For each patient, amplitude envelopes from 8 precordial leads (V1–V8) were analyzed across 76 frequency bands ranging from 150 to 1000 Hz. For each lead and frequency band, the ratio of the maximum and the area of envelopes before and after propafenone administration was calculated and subsequently averaged across frequency bands as well as leads. Results: Our results show that 11 out of 12 patients exhibited a reduction in the UHF component following sodium channel blockade. The median ratios before versus after propafenone administration were 1.51 and 1.29 for amplitude envelope maximum and area, respectively (p < 0.01). Conclusion: This study supports the hypothesis that the UHF components in the ECG are caused by the rapid opening of sodium channels.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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