Profile of cognitive deficits in schizophrenia and factor structure of the Czech MATRICS Consensus Cognitive Battery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081740%3A_____%2F20%3A00523209" target="_blank" >RIV/68081740:_____/20:00523209 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10412401 RIV/00064165:_____/20:10412401

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0920996420300803" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0920996420300803</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.schres.2020.02.004" target="_blank" >10.1016/j.schres.2020.02.004</a>

Result language

angličtina

Original language name

Profile of cognitive deficits in schizophrenia and factor structure of the Czech MATRICS Consensus Cognitive Battery

Original language description

We aimed to validate the Czech version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB is a test battery designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. The valid, reliable and replicable measurement of cognition in schizophrenia is of substantial importance for such clinical trial studies. We performed a psychometric analysis of the MCCB composite and domain scores based on ROC analysis of 67 schizophrenia patients and 67 age- and education-matched healthy controls from a total sample of 220 controls. Also, we correlated MCCB variables with scales measuring psychosocial functioning (Personal and Social Performance scale, PSP). The internal consistency of all 10 tests in the MCCB battery was good (Cronbach's α = 0.85 (95% CI [0.83, 0.88])). The discriminative validity for the detection of neurocognitive dysfunction in schizophrenia based on the area under the curve of MCCB composite T-score was ≥90% (95% CI [0.85, 0.96]) and all MCCB domains showed ps < .001. The MCCB global composite and the Speed of Processing domain score significantly predicted the PSP ratings. A confirmatory factor analysis on the whole control sample (N = 220) showed an optimal fit for a 6-factor in comparison to 1-factor solution. In conclusion, we found high discriminative validity for the Czech MCCB version, similar to the differentiation of schizophrenia versus healthy control groups in the original MCCB studies. We also established the factorial validity of the MCCB and showed that the overall composite of the MCCB predicts psychosocial functioning in the patient group.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

50101 - Psychology (including human - machine relations)

Project

<a href="/en/project/NV17-32445A" target="_blank" >NV17-32445A: Causes of assaultive behavior among patients with psychosis</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Schizophrenia Research

ISSN

0920-9964

e-ISSN

—

Volume of the periodical

218

Issue of the periodical within the volume

duben

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

85-92

UT code for WoS article

000541708500012

EID of the result in the Scopus database

2-s2.0-85079837566