Early and late infarct growth rate in ischemic stroke patients after successful endovascular treatment in early time window: correlation of imaging and clinical factors with clinical outcome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081740%3A_____%2F23%3A00574833" target="_blank" >RIV/68081740:_____/23:00574833 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/23:10466652 RIV/00216208:11120/23:43925921 RIV/00064173:_____/23:43925921

Result on the web

<a href="https://qims.amegroups.org/article/view/116200/pdf" target="_blank" >https://qims.amegroups.org/article/view/116200/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21037/qims-23-153" target="_blank" >10.21037/qims-23-153</a>

Result language

angličtina

Original language name

Early and late infarct growth rate in ischemic stroke patients after successful endovascular treatment in early time window: correlation of imaging and clinical factors with clinical outcome

Original language description

Background: The prospective study assessed infarct growth rate (IGR) in acute ischemic stroke (AIS) with large vessel occlusion (LVO) after recanalization in early time window. Early IGR (EIGR) and late IGR (LIGR) were correlated with imaging and clinical data, we searched for outcome predictors.Methods: We included 71 consecutive patients. Subjects underwent computed tomography perfusion (CTP) for ischemic core volume assessment at 99.0 minutes (median) from stroke onset, recanalization was performed at 78.0 minutes (median) from CTP. Final infarct volume (FIV) was measured on 24 & PLUSMN, 2 hours imaging follow-up. EIGR was calculated as the core volume/time between stroke onset and CTP, LIGR was calculated as FIV/time between CTP and imaging follow-up. Twenty-two subjects were assessed as poor outcome, 49 as good outcome. Group differences were tested by Mann-Whitney test and & chi,2 test. Bayesian logistic regression models were used to predict clinical outcome, Pearson correlations for the log transformed predictors.Results: Subjects with poor outcome were older, median age 78.0 [interquartile range (IQR): 71.8, 83.8] versus 68.0 (IQR: 57.0, 73.0) years, 95% confidence interval (CI): 6.00 to 16.00, P<0.001. Their stroke severity scale was higher, median 19.0 (IQR: 16.0, 20.0) versus 15.5 (IQR: 10.8, 18.0), 95% CI: 1.00 to 6.00, P<0.001. They had higher EIGR, median 23.9 (IQR: 6.4, 104.0) versus 6.7 (IQR: 1.7, 13.0) mL/h, 95% CI: 3.26 to 53.68, P=0.002, and larger core, median 52.5 (IQR: 13.1, 148.5) versus 10.0 (IQR: 1.4, 20.0) mL, 95% CI: 11.00 to 81.00, P<0.001. In subjects with poor outcome, infarct growth continued after thrombectomy with LIGR 2.0 (IQR: 1.2, 9.7) versus 0.3 (IQR: 0.0, 0.7) mL/h, 95% CI: 1.10 to 6.10, P<0.001, resulting in larger FIV, median 186.5 (IQR: 49.3, 280.8) versus 18.5 (IQR: 8.0, 34.0) mL, 95% CI: 55.30 to 214.00, P<0.001. Strong correlations among predictors were found e.g., core and EIGR (r=0.942), LIGR and FIV (r=0.779), core and FIV (r=0.761). Clinical outcome was best predicted using data from later measurements as FIV and LIGR.Conclusions: Data from later measurements were more predictive, there was no major benefit to use growth over volume data.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

50101 - Psychology (including human - machine relations)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Quantitative Imaging and Surgery

ISSN

2223-4292

e-ISSN

2223-4306

Volume of the periodical

13

Issue of the periodical within the volume

9

Country of publishing house

CN - CHINA

Number of pages

13

Pages from-to

5770-5782

UT code for WoS article

001046323400001

EID of the result in the Scopus database

2-s2.0-85171194021