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Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F18%3A00490181" target="_blank" >RIV/68081766:_____/18:00490181 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/18:10376585 RIV/00216224:14310/18:00104820

  • Result on the web

    <a href="http://dx.doi.org/10.1111/mec.14724" target="_blank" >http://dx.doi.org/10.1111/mec.14724</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/mec.14724" target="_blank" >10.1111/mec.14724</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context

  • Original language description

    Positive selection acting on Toll‐like receptors (TLRs) has been recently investigated to reveal evolutionary mechanisms of host–pathogen molecular co‐adaptation. Much of this research, however, has focused mainly on the identification of sites predicted to be under positive selection, bringing little insight into the functional differences and similarities among species and a limited understanding of convergent evolution in the innate immune molecules. In this study, we provide evidence of phenotypic variability in the avian TLR4 ligand‐binding region (LBR), the direct interface between host and pathogen molecular structures. We show that 55 passerine species vary substantially in the distribution of electrostatic potential on the surface of the receptor, and based on these distinct patterns, we identified four species clusters. Seven of the 34 evolutionarily nonconservative and positively selected residues correspond topologically to sites previously identified as being important for lipopolysaccharide, lipid IVa or MD‐2 binding. Five of these positions codetermine the identity of the charge clusters. Groups of species that host‐related communities of pathogens were predicted to cluster based on their TLR4 LBR charge. Despite some evidence for convergence among taxa, there were no clear associations between the TLR4 LBR charge distribution and any of the general ecological characteristics compared (migration, latitudinal distribution and diet). Closely related species, however, mostly belonged to the same surface charge cluster indicating that phylogenetic constraints are key determinants shaping TLR4 adaptive evolution. Our results suggest that host innate immune evolution is consistent with Fahrenholz's rule on the cospeciation of hosts and their parasites.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Ecology

  • ISSN

    0962-1083

  • e-ISSN

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    13

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    13

  • Pages from-to

    2871-2883

  • UT code for WoS article

    000436113300008

  • EID of the result in the Scopus database

    2-s2.0-85048986837