Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F18%3A00490181" target="_blank" >RIV/68081766:_____/18:00490181 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/18:10376585 RIV/00216224:14310/18:00104820

Result on the web

<a href="http://dx.doi.org/10.1111/mec.14724" target="_blank" >http://dx.doi.org/10.1111/mec.14724</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/mec.14724" target="_blank" >10.1111/mec.14724</a>

Result language

angličtina

Original language name

Signatures of diversifying selection and convergence acting on passerine Toll‐like receptor 4 in an evolutionary context

Original language description

Positive selection acting on Toll‐like receptors (TLRs) has been recently investigated to reveal evolutionary mechanisms of host–pathogen molecular co‐adaptation. Much of this research, however, has focused mainly on the identification of sites predicted to be under positive selection, bringing little insight into the functional differences and similarities among species and a limited understanding of convergent evolution in the innate immune molecules. In this study, we provide evidence of phenotypic variability in the avian TLR4 ligand‐binding region (LBR), the direct interface between host and pathogen molecular structures. We show that 55 passerine species vary substantially in the distribution of electrostatic potential on the surface of the receptor, and based on these distinct patterns, we identified four species clusters. Seven of the 34 evolutionarily nonconservative and positively selected residues correspond topologically to sites previously identified as being important for lipopolysaccharide, lipid IVa or MD‐2 binding. Five of these positions codetermine the identity of the charge clusters. Groups of species that host‐related communities of pathogens were predicted to cluster based on their TLR4 LBR charge. Despite some evidence for convergence among taxa, there were no clear associations between the TLR4 LBR charge distribution and any of the general ecological characteristics compared (migration, latitudinal distribution and diet). Closely related species, however, mostly belonged to the same surface charge cluster indicating that phylogenetic constraints are key determinants shaping TLR4 adaptive evolution. Our results suggest that host innate immune evolution is consistent with Fahrenholz's rule on the cospeciation of hosts and their parasites.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Ecology

ISSN

0962-1083

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

13

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

2871-2883

UT code for WoS article

000436113300008

EID of the result in the Scopus database

2-s2.0-85048986837