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Modelling invasive pathogen load from non-destructive sampling data

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F19%3A00499378" target="_blank" >RIV/68081766:_____/19:00499378 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26210/19:PU131273 RIV/62157124:16270/19:43877448 RIV/00216224:14110/19:00113549

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0022519318306258?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022519318306258?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jtbi.2018.12.026" target="_blank" >10.1016/j.jtbi.2018.12.026</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Modelling invasive pathogen load from non-destructive sampling data

  • Original language description

    Where microbes colonizing skin surface may help maintain organism homeostasis, those that invade liv- ing skin layers cause disease. In bats, white-nose syndrome is a fungal skin infection that affects animals during hibernation and may lead to mortality in severe cases. Here, we inferred the amount of fungus that had invaded skin tissue of diseased animals. We used simulations to estimate the unobserved disease severity in a non-lethal wing punch biopsy and to relate the simulated pathology to the measured fungal load in paired biopsies. We found that a single white-nose syndrome skin lesion packed with spores and hyphae of the causative agent, Pseudogymnoascus destructans , contains 48.93 pg of the pathogen DNA, which amounts to about 1560 P destructans genomes in one skin lesion. Relating the information to the known UV fluorescence in Nearctic and Palearctic bats shows that Nearctic bats carry about 1.7 μg of fun- gal DNA per cm 2 , whereas Palearctic bats have 0.04 μg cm −2 of P. destructans DNA. With the information on the fungal load that had invaded the host skin, the researchers can now calculate disease severity as a function of invasive fungal growth using non-destructive UV light transillumination of each bat ʼs wing membranes. Our results will enable and promote thorough disease severity assessment in protected bat species without the need for extensive animal and laboratory labor sacrifices.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Theoretical Biology

  • ISSN

    0022-5193

  • e-ISSN

  • Volume of the periodical

    464

  • Issue of the periodical within the volume

    March

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    98-103

  • UT code for WoS article

    000457204500009

  • EID of the result in the Scopus database

    2-s2.0-85059111717