Relaxed selection limits lifespan by increasing mutation load

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F19%3A00506728" target="_blank" >RIV/68081766:_____/19:00506728 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cell.2019.06.004" target="_blank" >http://dx.doi.org/10.1016/j.cell.2019.06.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cell.2019.06.004" target="_blank" >10.1016/j.cell.2019.06.004</a>

Result language
angličtina
Original language name
Relaxed selection limits lifespan by increasing mutation load
Original language description
To uncover the selective forces shaping life-history trait evolution across species, we investigate the genomic basis underlying adaptations to seasonal habitat desiccation in African killifishes, identifying the genetic variants associated with positive and relaxed purifying selection in 45 killifish species and 231 wild individuals distributed throughout sub-Saharan Africa. In annual species, genetic drift led to the expansion of nuclear and mitochondrial genomes and caused the accumulation of deleterious genetic variants in key life-history modulating genes such as mtor, insr, ampk, foxo3, and polg. Relaxation of purifying selection is also significantly associated with mitochondrial function and aging in human populations. We find that relaxation of purifying selection prominently shapes genomes and is a prime candidate force molding the evolution of lifespan and the distribution of genetic variants associated with late-onset diseases in different species. Video Abstract. Studying the genomic changes accompanying the repeated evolution of short lifespan in 45 African killifish species reveals that neutral genetic drift, rather than adaptive evolution, explains the accumulation of deleterious gene variants affecting lifespan and aging.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project
<a href="/en/project/GA19-01781S" target="_blank" >GA19-01781S: The sources of intra-population heterogeneity in senescence</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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