Molecular detection and genomic characterization of diverse hepaciviruses in African rodents

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F21%3A00544530" target="_blank" >RIV/68081766:_____/21:00544530 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/21:00123299

Result on the web

<a href="https://academic.oup.com/ve/article/7/1/veab036/6225056" target="_blank" >https://academic.oup.com/ve/article/7/1/veab036/6225056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ve/veab036" target="_blank" >10.1093/ve/veab036</a>

Result language

angličtina

Original language name

Molecular detection and genomic characterization of diverse hepaciviruses in African rodents

Original language description

Hepatitis C virus (HCV, genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins of HCV still remain unresolved. Motivated by recent findings of divergent hepaciviruses in rodents and a plausible African origin of HCV genotypes, we have screened a large collection of small mammals samples from seven sub-Saharan African countries. Out of 4,303 samples screened, eighty were found positive for the presence of hepaciviruses in twenty-nine different host species. We, here, report fifty-six novel genomes that considerably increase the diversity of three divergent rodent hepacivirus lineages. Furthermore, we provide strong evidence for hepacivirus co-infections in rodents, which were exclusively found in four sampled species of brush-furred mice. We also detect evidence of recombination within specific host lineages. Our study expands the available hepacivirus genomic data and contributes insights into the relatively deep evolutionary history of these pathogens in rodents. Overall, our results emphasize the importance of rodents as a potential hepacivirus reservoir and as models for investigating HCV infection dynamics.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Virus Evolution

ISSN

2057-1577

e-ISSN

2057-1577

Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

veab036

UT code for WoS article

000920141200033

EID of the result in the Scopus database

2-s2.0-85110384221