Temperature-dependent in vitro hepatocytotoxicity of insecticides in bats.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F24%3A00598350" target="_blank" >RIV/68081766:_____/24:00598350 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16270/24:43881508
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1382668924001844" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668924001844</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2024.104544" target="_blank" >10.1016/j.etap.2024.104544</a>
Alternative languages
Result language
angličtina
Original language name
Temperature-dependent in vitro hepatocytotoxicity of insecticides in bats.
Original language description
Heterothermic insectivorous bats are supposed to experience differential adverse effects of insecticidal pollutants depending on their seasonal and/or daily variation of metabolic and detoxification rates. Here, we investigated effects of imidacloprid, cypermethrin and fipronil on Nyctalus noctula bat-derived hepatocytes through cytotoxicity, cell inhibition and death at different concentrations (0.01, 0.1, 1, 10, 100, 1000 mug/ml), exposure times (10, 24, 48 hrs), incubation temperatures simulating hibernation (8 °C), daily torpor (20 °C), normothermy (37 °C) and active flight (40 °C), and cytochrome P450 addition. Toxic effects were significantly influenced by temperature (p < 0.05), with strong cytotoxicity after 10 hour exposure to fipronil or cypermethrin at 37 and 40 °C, cell replication inhibition (all insecticides at 8 °C) and cellular stimulation, with slight culture proliferation after 48 hours (all insecticides at 40 °C). Replacing protected chiropterans with cell cultures is a way to assess and extrapolate risks of insecticides for bats.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Pharmacology
ISSN
1382-6689
e-ISSN
1872-7077
Volume of the periodical
111
Issue of the periodical within the volume
October
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
104544
UT code for WoS article
001312633900001
EID of the result in the Scopus database
2-s2.0-85203174409