Convergence of gut phage communities but not bacterial communities following wild mouse bacteriophage transplantation into captive house mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F24%3A00599122" target="_blank" >RIV/68081766:_____/24:00599122 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/24:10486199

Result on the web

<a href="https://academic.oup.com/ismej/article/18/1/wrae178/7758143?login=true" target="_blank" >https://academic.oup.com/ismej/article/18/1/wrae178/7758143?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ismejo/wrae178" target="_blank" >10.1093/ismejo/wrae178</a>

Result language

angličtina

Original language name

Convergence of gut phage communities but not bacterial communities following wild mouse bacteriophage transplantation into captive house mice

Original language description

Bacteriophages are abundant components of vertebrate gut microbial communities, impacting bacteriome dynamics, evolution, and directly interacting with the superhost. However, knowledge about gut phageomes and their interaction with bacteriomes in vertebrates under natural conditions is limited to humans and non-human primates. Widely used specific-pathogen-free (SPF) mouse models of host-microbiota interactions have altered gut bacteriomes compared to wild mice, and data on phageomes from wild or other non-SPF mice are lacking. We demonstrate divergent gut phageomes and bacteriomes in wild and captive non-SPF mice, with wild mice phageomes exhibiting higher alpha-diversity and interindividual variability. In both groups, phageome and bacteriome structuring mirrored each other, correlating at the individual level. Re-analysis of previous data from phageomes of SPF mice revealed their enrichment in Suoliviridae crAss-like phages compared to our non-SPF mice. Disrupted bacteriomes in mouse models can be treated by transplanting healthy phageomes, but the effects of phageome transplants on healthy adult gut microbiota are still unknown. We show that experimental transplantation of phageomes from wild to captive mice did not cause major shifts in recipient phageomes. However, the convergence of recipient-to-donor phageomes confirmed that wild phages can integrate into recipient communities. The differences in the subset of integrated phages between the two recipient mouse strains illustrate the context-dependent effects of phage transplantation. The transplantation did not impact recipient gut bacteriomes. This resilience of healthy adult gut microbiomes to the intervention has implications for phage allotransplantation safety.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/GA19-19307S" target="_blank" >GA19-19307S: Evolutionary patterns of gastrointestinal microbiota on murine rodents example</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The ISME Journal

ISSN

1751-7362

e-ISSN

1751-7370

Volume of the periodical

18

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

wrae178

UT code for WoS article

001322029100001

EID of the result in the Scopus database

2-s2.0-85206312275