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Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F04%3A00109653" target="_blank" >RIV/68378041:_____/04:00109653 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II

  • Original language description

    Actin is abundant in the nucleus and has been implicated in transcription; however, the nature of this involvement has not been established. Here we demonstrate that beta-actin is critically involved in transcription because antibodies directed against beta-actin, but not muscle actin, inhibited transcription in vivo and in vitro

  • Czech name

    Aktin je součástí pre-iniciačního komplexu a je nezbytný pro transkripci pomocí RNA polymerázy II

  • Czech description

    Actin se vyskytuje v buňečném jádře v hojném množství a existují důkazy, většinou nepřímé, pro jeho účast v transkripci. Povaha této účasti však zatím nebyla zjištěna. Nám se podařilo prokázat, že aktin se podílí na transkripci podstatným způsobem, neboťprotilátky proti beta-aktinu inhibovaly transkripci in vivo a in vitro. Tato inhibice nebyla pozorována při použití protilátek proti svalovému aktinu

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EA - Morphology and cytology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Nature Cell Biology

  • ISSN

    1465-7392

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    1094-1101

  • UT code for WoS article

  • EID of the result in the Scopus database