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An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00347664" target="_blank" >RIV/68378041:_____/10:00347664 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/10:10081467

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts

  • Original language description

    The genotoxicity of the organic extracts (EOMs) from three size fractions of aerosols (ranging from 0.17 to 10?m and collected in 4 localities differing in the extent of pollution) was compared using the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation. It was found that most of the observed genotoxicity was connected with a fine particulate matter fraction (<1?m). These fine fractions bound the highest amount of c-PAHs in all aerosol sites, which might be related to their higher specific surface. As for aerosol mass, both fine and condensational fractions are effective carriers of c-PAHs. Similarly, the DNA adduct levels per m3 of air were highest for the fine fraction and a strong correlation was found between the c-PAHs and DNA adduct levels induced by EOMs in all the localities and for various size fractions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology Letters

  • ISSN

    0378-4274

  • e-ISSN

  • Volume of the periodical

    198

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    000282855300002

  • EID of the result in the Scopus database