Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00349469" target="_blank" >RIV/68378041:_____/10:00349469 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

Original language description

We monitored changes in the astroglia morphology throughout the age-dependent progression of AD, in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the temporal progression of the human disease. We found astrocytic atrophyin both the dentate gyrus and hippocampal CA1 field from middle age (12 months onwards). However, astroglial atrophy appears as a generalised process, astrocytes that surround neuritic plaques are clearly hypertrophic which suggest differential effects of AD on astroglial populations depending on their association with plaques which account for the progressive disruption of connectivity in neural networks and neurotransmitters imbalance which underlie cognitive impairments observed in AD.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Glia

ISSN

0894-1491

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000276678500008

EID of the result in the Scopus database

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