Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00382997" target="_blank" >RIV/68378041:_____/12:00382997 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8196
Result on the web
<a href="http://dx.doi.org/10.1111/j.1469-7580.2012.01536.x" target="_blank" >http://dx.doi.org/10.1111/j.1469-7580.2012.01536.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1469-7580.2012.01536.x" target="_blank" >10.1111/j.1469-7580.2012.01536.x</a>
Alternative languages
Result language
angličtina
Original language name
Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease
Original language description
We analysed the astrocytic cytoskeletal changes within the medial prefrontal cortex (mPFC) of a 3xTg-AD mouse model by measuring the surface area and volume of GFAP-positive profiles in relation to presence of A?, compared to control animals at differentages. 3xTg-AD animals showed clear astroglial cytoskeletal atrophy, which appeared at an early age of 3 months and remained up to 18 months old. This atrophy was independent of A? accumulation. Our results indicate that the progressive reduction in astrocytic branching and domain in the mPFC can account for the integrative dysfunction leading to the cognitive deficits and memory disturbances observed in AD.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Anatomy
ISSN
0021-8782
e-ISSN
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Volume of the periodical
221
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
252-262
UT code for WoS article
000306922500006
EID of the result in the Scopus database
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