Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00356231" target="_blank" >RIV/68378041:_____/11:00356231 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genetic, Biochemical and Environmental Factors Associated with Pregnancy Outcomes in Newborns from the Czech Republic

Original language description

We investigated associations between the levels of 8-oxo-7,8-dihydro-2?-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes and pregnancy outcomes (intrauterine growth restriction, IUGR, low birth weight, LBW). Multivariate-adjusted logistic regression revealed that above-median 8-oxodG levels are the only factor significantly associated with the risk of IUGR (OR; 95% CI: 1.56; 1.07-2.37; p=0.022). Above-median levels of 8-oxodG were associated with an increased risk of LBW (OR; 95% CI: 1.88; 1.15- 3.06; p=0.011). Other variables associated with LBW included the newborn?s gender and gestational age, maternal smoking and haplotypes in the promoter region of the gene encoding mannose-binding lectin 2.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

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Project

<a href="/en/project/SP%2F1B3%2F50%2F07" target="_blank" >SP/1B3/50/07: The influence of genome on the interaction of human organism and environment</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Health Perspectives

ISSN

0091-6765

e-ISSN

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Volume of the periodical

119

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

000286803400031

EID of the result in the Scopus database

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