Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00365854" target="_blank" >RIV/68378041:_____/11:00365854 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.06.001" target="_blank" >10.1016/j.mrfmmm.2011.06.001</a>
Alternative languages
Result language
angličtina
Original language name
Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic
Original language description
The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
ISSN
0027-5107
e-ISSN
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Volume of the periodical
713
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
76-82
UT code for WoS article
000293930400009
EID of the result in the Scopus database
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