Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00425641" target="_blank" >RIV/60077344:_____/13:00425641 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/13:00384434
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/ges058" target="_blank" >http://dx.doi.org/10.1093/mutage/ges058</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/ges058" target="_blank" >10.1093/mutage/ges058</a>

Result language
angličtina
Original language name
Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II. Chromosomal aberrations and oxidative stress
Original language description
The study indentified the effect of exposure to benzo[a]pyrene, particulate matter (PM2.5) and benzene on oxidative stress markers (8-oxodG, 15-F2t-IsoP and protein carbonyls) and cytogenetic parameters (stable and unstable chromosomal aberrations). Thesamples were collected from subjects from the Ostrava region and Prague in three seasons (winter 2009, summer 2009, and winter 2010). Despite several fold higher concentrations of air pollutants in the Ostrava region, the levels of stable aberrations were mostly comparable in both locations. The frequency of unstable aberrations was unexpectedly significantly lower in the Ostrava region subjects in both seasons of 2009. Urinary excretion of 8-oxodG did not differ between locations in either season. Lipid peroxidation measured as levels of 15-F2t-IsoP in blood plasma was elevated in the Ostrava subjects sampled in 2009. Protein oxidation was higher in Prague samples collected in summer 2009. Multivariate analyses showed a negative associ
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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