DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00360452" target="_blank" >RIV/68378041:_____/11:00360452 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.toxlet.2011.02.005" target="_blank" >http://dx.doi.org/10.1016/j.toxlet.2011.02.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxlet.2011.02.005" target="_blank" >10.1016/j.toxlet.2011.02.005</a>

Result language

angličtina

Original language name

DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay

Original language description

The genotoxic acitivity of complex mixtures of organic extracts from urban air particles (PM2.5) collected in various localities of the Czech Republic with different levels of air pollution was compared. As markers of genotoxic potential, DNA adduct levels and oxidative DNA damage (8-oxodG levels) induced by EOMs in an acellular assay of calf thymus DNA coupled with 32P-postlabeling (DNA adducts) and ELISA (8-oxodG) were employed. The results indicate that the industrial emissions prevailing in Ostrava-Bartovice represent a substantially higher genotoxic risk that mostly traffic-related emissions in Ostrava-Poruba. B[a]P and c-PAH contents in EOMs are the most important factors relating to their genotoxic potential.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DN - Environmental impact on health

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

—

Volume of the periodical

202

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

186-192

UT code for WoS article

000290778600005

EID of the result in the Scopus database

—