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Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00377764" target="_blank" >RIV/68378041:_____/12:00377764 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/12:00377764 RIV/00027162:_____/12:#0000942

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.mrgentox.2011.12.030" target="_blank" >http://dx.doi.org/10.1016/j.mrgentox.2011.12.030</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.mrgentox.2011.12.030" target="_blank" >10.1016/j.mrgentox.2011.12.030</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes

  • Original language description

    The spontaneously immortalized human keratinocytes HaCaT were used in order to evaluate the genotoxic potential of 7H-dibenzo[c,g]carbazole (DBC), a known hepatocarcinogen and sarcomagen, and its derivatives, 5,9-dimethyl-DBC (DiMeDBC) and N-methyl-DBC (N-MeDBC), which manifest specific tropism to the liver and skin. The study demonstrates that the absence of drug-metabolizing enzyme(s) involved in DiMeDBC metabolism may contribute substantially to the tissue-specific genotoxicity of this hepatocarcinogen.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    DN - Environmental impact on health

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/2B08005" target="_blank" >2B08005: New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutation Research - Genetic Toxicology and Environmental Mutagenesis

  • ISSN

    1383-5718

  • e-ISSN

  • Volume of the periodical

    743

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    91-98

  • UT code for WoS article

    000301966600012

  • EID of the result in the Scopus database