Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00377764" target="_blank" >RIV/68378041:_____/12:00377764 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00377764 RIV/00027162:_____/12:#0000942
Result on the web
<a href="http://dx.doi.org/10.1016/j.mrgentox.2011.12.030" target="_blank" >http://dx.doi.org/10.1016/j.mrgentox.2011.12.030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrgentox.2011.12.030" target="_blank" >10.1016/j.mrgentox.2011.12.030</a>
Alternative languages
Result language
angličtina
Original language name
Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes
Original language description
The spontaneously immortalized human keratinocytes HaCaT were used in order to evaluate the genotoxic potential of 7H-dibenzo[c,g]carbazole (DBC), a known hepatocarcinogen and sarcomagen, and its derivatives, 5,9-dimethyl-DBC (DiMeDBC) and N-methyl-DBC (N-MeDBC), which manifest specific tropism to the liver and skin. The study demonstrates that the absence of drug-metabolizing enzyme(s) involved in DiMeDBC metabolism may contribute substantially to the tissue-specific genotoxicity of this hepatocarcinogen.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/2B08005" target="_blank" >2B08005: New approaches to study the toxicity of the air pollution and their contribution to assess limits for selected pollutants.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
ISSN
1383-5718
e-ISSN
—
Volume of the periodical
743
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
91-98
UT code for WoS article
000301966600012
EID of the result in the Scopus database
—