Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00379159" target="_blank" >RIV/68378041:_____/12:00379159 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8160

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0036816" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0036816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0036816" target="_blank" >10.1371/journal.pone.0036816</a>

Result language

angličtina

Original language name

Polydendrocytes Display Large Lineage Plasticity following Focal Cerebral Ischemia

Original language description

Here we show that polydendrocytes participate in CNS repair following focal cerebral ischemia. We followed their fate after a permanent middle cerebral artery occlusion (MCAo) in adult NG2creBAC:ZEG double transgenic mice, in which enhanced green fluorescent protein (EGFP) is expressed in polydendrocytes and their progeny. We found that 3 days after MCAo the EGFP(+) cells markedly proliferate,. however, in later phases after MCAo they give rise to a subpopulation of reactive astrocytes and moreover, some EGFP(+) cells expressed doublecortin and displayed membrane properties typical for neural precursor cells, Taken together, our data indicate that polydendrocytes in the dorsal cortex display multipotent differentiation potential after focal ischemia.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000305336400038

EID of the result in the Scopus database

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